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Medieval English half-vampire. Her mother survived conceiving her because her mother was a witch and survived bearing her because she was a witch. 

Circumstance alt of Moka Akashiya from Rosario+Vampire

Lovecraft Mythos but with the racism and classism etc. torn out and replaced with transhumanism.  I realize technically this is a "fandom" setting but with Lovecraft as far out of copyright as he is, enh. 

Fantasy kitchen sink world where God sucked and then fucked off for mysterious reasons. Influenced strongly by Supernatural but distinct enough not to count as a fandom setting. For one thing, the angels aren't dicks. 

Demon from Apostasy. Ex-human. Died in the siege of Magdeburg in 1631. 

Anise instance from Kappa's Curse setting. 

High Fantasy setting with tripartite general-use magic: Witches, Wizards and Warlocks. 

Origin of the Anise template. From Ankeda. 

A dimension filled with scraps of magical light. Ordinary matter is comparatively rare but due to a long history of contact with more conventional dimensions it's generally filled with breathable air in populated areas. 

Setting of Smallville TV show

Birth name Aiza-El, she takes the place of Clark Kent from Smallville. 

Water spirit from a world where those are commonly enslaved by human magic-users. 

Fantasy setting with angels and demons, each of whom have their own dimension adjacent to the human one. Angel society is kinda messed up but mostly aligned with human well-being. Demon societies are mostly postscarcity utopias except for the thing where they ...

Numina instance of Elodea. Half-human, half-demon, raised in the human world by her human mother, has spent her life using her demonic shapeshifting powers to pass as human. 

Eliza instance from Apostasy. 

Earth instance of Sissy. 

Setting: Young Justice. Circumstance alt of Superboy except with Wonder Woman instead of Superman. 

Dandelion instance from MohD; possesses the titular Domain power. World's most benevolent crime boss.